Endocrine Abstracts

Background: Few effective medical treatment options are available for adrenocortical carcinoma (ACC). Intensive efforts are therefore going on for exploring novel pathways and treatment targets.Objective: To perform a proteomic and pathway analysis on a 9-cisRA (9-cis retinoic acid) and mitotane-treated ACC xenograft model.Methods: 43 male SCID mice xenografted with NCI-H295R cells were treated in four groups (i. control, ii. 5 mg/...

Introduction: Metabolic syndrome (MetS) is a cluster of interconnected factors that directly increase the risk of DM2 and CVD. Stevia rebaudiana (a low calorie natural sweetener) and its compounds are known for anti-hyperglycemic, anti-inflammatory, anti-oxidant, anti-hypertensive effects.Methods: Thirty-eight patients (age 47.3±10.3 years) (nmales=14, nfemales=24) with MetS (NCEP/ATPIII criteria) wer...

Background: Metabolic complications with obesity are frequent in childhood acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). Childhood onset Craniopharyngioma (CP) survivors without hypothalamic (HT) involvement are spared gross obesity. Magnetic resonance diffusion tensor imaging (DTI) provides information of microstructure function of the brain and quantified as fractional anisotrophy (FA), mean diffusivity (MD), axial and radial diffusivi...

Early-life stress (ES) is associated with increased vulnerability to cognitive impairments as well as metabolic disorders like obesity later in life. We investigate the role of a synergistic effect of stress, metabolic factors, nutrition and the neuroimmune system in this early-life induced programming. We use an established model of chronic ES and expose mice to limited nesting and bedding material during first postnatal week and study the central and peripheral systems under...

GLP-1 is a gut hormones with insulinotropic effects. GLP-1 is expressed at the hypothalamus having regulatory functions in food intake and neuroendocrine corticoadrenal axis (HPA). Energy balance and HPA have deep influence in the gonadal function of mammals. Exendin-4 (Ex4) is a potent agonist for the GLP-1 receptor.Objectives: To evaluate the effects of native GLP-1 (7–36)-NH2(GLP-1) and Ex4 in the function of the reproductive system in adulthood ...

A 32-year-old women initially presented with recurrent kidney stones and was found to have nephrocalcinosis. She was found to normocalcaemic but hypercalciuric, with a plasma ionized calcium at upper-limit of normal and a PTH in lower normal range. One year later, during the first trimester of a pregnancy, she presented with severe hypercalcaemia, hypercalciuria and suppression of PTH. Extensive investigations for causes of hypercalcaemia excluded hyperparathyroidism, other en...

Background: Metabolic complications (obesity, lipid abnormalities, and insulin resistance) are prevalent in acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). The hypothalamus (HT) is a complex area involved in endocrine function and metabolic control. In ALL survivors, assessment of the volume of the HT in relation to metabolic parameters including ghrelin, a peptide stimulating food intake, has not been performed previously.<p class="ab...

Introduction: Cushing’s disease (CD) is a rare endocrine disorder characterized by endogenous hypercortisolism, which is associated with metabolic and psychiatric disorders. It is essential to understand the impact of normalization of serum cortisol in the evolution of these comorbidities.Aims: To evaluate the evolution of metabolic and psychiatric disorders after biochemical control of hypercortisolism in patients with CD.Met...

Introduction: Cushing’s disease (CD) presents a marked female preponderance, with a female-to-male ratio of 3–8:1, but whether this skewed gender distribution has any relevance to the presentation and outcomes of CD is not well understood.Aim: To evaluate sex-related differences in the presentation of CD, as regards: biochemical indices of hypercortisolism; complications of disease and outcomes.Methods: Observational, ret...

Journal of Molecular Endocrinology 2013 50 375–387. DOI: 10.1530/JME-12-0219...